Autophagy regulates levels of tumor suppressor enzyme protein phosphatase 6
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چکیده
منابع مشابه
PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms.
We show in this study that PTEN regulates p53 protein levels and transcriptional activity through both phosphatase-dependent and -independent mechanisms. The onset of tumor development in p53(+/-);Pten(+/-) mice is similar to p53(-/-) animals, and p53 protein levels are dramatically reduced in Pten(-/-) cells and tissues. Reintroducing wild-type or phosphatase-dead PTEN mutants leads to a signi...
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ژورنال
عنوان ژورنال: Cancer Science
سال: 2020
ISSN: 1347-9032,1349-7006
DOI: 10.1111/cas.14662